tert-Butylsulfinamide, (R)-(+)- → HCID 89874429, compound

HRID 715464Notes

Reaction equation

HRID 715464 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:16](=O)[CH3:17])[N:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:15])([F:14])[CH:11]([F:13])[F:12].[CH3:19][C:20]([S@:23]([NH2:25])=[O:24])([CH3:22])[CH3:21]>>[CH3:19][C:20]([S@:23]([NH:25][CH:16]([C:4]1[N:5]=[N:6][C:7]([O:8][CH2:9][C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])=[C:2]([CH3:1])[CH:3]=1)[CH3:17])=[O:24])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874639HCID 89874639, compound

Product 1

HCID 89874429HCID 89874429, compoundYield 66%

Procedure

The title compound is prepared in 66% yield (1.14 g, yellow oil) from 1-(5-methyl-6-(2,2,3,3-tetrafluoropropoxy)pyridazin-3-yl)ethanone (1.22 g, 4.61 mmol, Step-5) and (R)-2-methylpropane-2-sulfinamide (839 mg, 6.92 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-f3fe9d89556f4c5ab7cde2e8611ed50b
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

Loading…