HuagongsheHuagongshe Chemistry Print Report · For research reference only
Decylamine → Methyl 4-(2,2-difluoropropoxy)-3-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Decylamine | HCID 8916 | — |
| Reactant | Methyl 4-hydroxy-3-methylbenzoate | HCID 11240684 | — |
| Reactant | 2,2-Difluoropropyl 1,1,1-trifluoromethanesulfonate | HCID 58747012 | — |
| Product | Methyl 4-(2,2-difluoropropoxy)-3-methylbenzoate | HCID 89874160 | 76% |
Reaction Steps
The title compound is prepared in 76% yield (2.09 g, white solid) from methyl 4-hydroxy-3-methylbenzoate (1.86 g, 11.2 mmol) and 2,2-difluoropropyl trifluoromethanesulfonate (6.37 g, 27.9 mmol) in a similar manner to Step-1 of Amine-10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-eb8f216ad74d4e88a79459bbfda79bed |
| Source note | uspto-grants-2015_11 |