tert-Butylsulfinamide, (R)-(+)- → HCID 89875586, compound

HRID 715476Notes

Reaction equation

HRID 715476 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:14](=O)[CH3:15])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[CH3:11].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:15])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[CH3:11]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89875578HCID 89875578, compound

Product 1

HCID 89875586HCID 89875586, compoundYield 80%

Procedure

The title compound is prepared in 80% yield (696 mg, colorless oil) from 1-(3-chloro-4-(2,2-difluoropropoxy)phenyl)ethanone (610 mg, 2.45 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (446 mg, 3.68 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-ca920a704f034b5dbd6df33a477c06d9
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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