Sodium Methoxide → HCID 86717591, compound

Participants

Reaction Conditions

Reaction Steps

A 20 mL microwave vial was charged with ethyl (5-chloropyrazin-2-yl)carbamate (500 mg, 2.480 mmol) and 22% sodium methoxide in MeOH (10 mL). The tube was sealed and heated to 100° C. for 6 h. The reaction mixture was then concentrated, diluted between DCM and 2N HCl. The layers were separated and the aqueous layer was extracted with DCM (2×). The combined organic layers were washed with 2N HCl, brine, eluted through a phase separator and concentrated to afford methyl (5-methoxypyrazin-2-yl)carbamate as a brown oil (100 mg, 22.01% yield). MS (m/z) 184 (M+H+).

Provenance & Evidence