Trifluoroacetic acid → HCID 57365150, compound

Participants

Reaction Steps

tert-Butyl 1-(4-bromophenyl)piperidin-4-ylcarbamate (365 mg) is dissolved in dichloromethane (10 mL), treated with trifluoroacetic acid (780 μL) and stirred for 6 hours at room temperature. Then the mixture is partitioned between dichloromethane and saturated aqueous K2CO3 solution and stirred vigorously for 30 minutes. The phases are separated and the organic phase is washed with saturated aqueous K2CO3 solution. The organic phase is dried (MgSO4) and concentrated to give the title compound. LC (method 2): tR=0.93 min; Mass spectrum (ESI+): m/z=255 [M+H]+.

Provenance & Evidence