Methyl chloroformate → HCID 178502258, compound

Participants

Reaction Steps

(cis)-4-(4-(2-((3R,3aR,6R,6aS)-6-(tert-Butyldimethylsilyloxy)hexahydrofuro[3,2-b]furan-3-yloxy)-6-chloro-3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)cyclohexanamine (50 mg) and triethylamine (30 μL) are dissolved in dichloromethane (2 mL), treated with methyl chloroformate (11 μL) and stirred for 2 hours. The mixture is partitioned between dichloromethane and saturated aqueous NH4Cl solution. The organic phase is dried (MgSO4) and concentrated. The crude product is used directly in the next step. LC (method 4): tR=1.19 min; Mass spectrum (ESI+): m/z=773 [M+H]+.

Provenance & Evidence