1-Pyrrolidinecarbonyl chloride → HCID 178455388, compound

Participants

Reaction Conditions

Reaction Steps

The title compound is prepared from (trans)-4-(4-(2-((3R,3aR,6R,6aS)-6-(tert-butyldimethylsilyloxy)hexahydrofuro[3,2-b]furan-3-yloxy)-6-chloro-3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)cyclohexanol and pyrrolidine-1-carbonyl chloride following a procedure analogous to that described for Intermediate 12 Step 2 but heating the mixture for 48 hours at 100° C. LC (method 5): tR=1.32 min.

Provenance & Evidence