1-Pyrrolidinecarbonyl chloride → HCID 178455387, compound

Participants

Reaction Conditions

Reaction Steps

(cis)-4-(4-(2-((3R,3aR,6R,6aS)-6-(tert-Butyldimethylsilyloxy)hexahydrofuro[3,2-b]furan-3-yloxy)-6-chloro-3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)cyclohexanol (50 mg) is dissolved in pyridine (1 mL), treated with pyrrolidine-1-carbonyl chloride (80 μL) and stirred for 12 hours at 70° C. Pyrrolidine-1-carbonyl chloride (160 μL) is added and the mixture is stirred for 48 hours at 100° C.

Provenance & Evidence