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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 71559생성일: 2026년 10월 26일

Lithium Hydroxide → N2-(2-carboxyindol-5-yl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine

https://huagongshe.com/reaction/71559

반응식

참여 물질

역할이름HCID투입량
반응물Lithium HydroxideHCID 3939—
반응물N4-(4-tert-butylphenyl)-5-fluoro-N2-(2,3-dihydro-2-carboxybenzofuran-5-yl)-2,4-pyrimidinediamineHCID 22060366—
반응물N2-(2-ethoxycarbonylindol-5-yl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamineHCID 22060970—
생성물N2-(2-carboxyindol-5-yl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamineHCID 22060545—

반응 단계

In a manner similar to the preparation of N4-(4-tert-butylphenyl)-5-fluoro-N2-[2,3-dihydro-2-(carboxy)benzofuran-5-yl]-2,4-pyrimidinediamine, N2-(2-ethoxycarbonylindol-5-yl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine upon LiOH treatment gave N2-(2-carboxyindol-5-yl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine. 1H NMR (CD3OD): δ 7.83 (m, 1H), 7.73 (s, 1H), 7.50 (bd, 1H, J=8.7 Hz), 7.30-7.11 (m, 5H), 6.68 (bd, 1H); LCMS: ret. time: 16.50 min.; purity: 97%; MS (m/e): 380 (MH+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08822685B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-7712d3ee7555407a84ad027cc8313aca
출처 메모uspto-grants-2014_09