Triethylamine → HCID 178455391, compound

Participants

Reaction Steps

(cis)-4-(4-(2-((3R,3aR,6R,6aS)-6-(tert-Butyldimethylsilyloxy)hexahydrofuro[3,2-b]furan-3-yloxy)-6-chloro-3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)cyclohexanol (250 mg) and triethylamine (240 μL) are dissolved in dichloromethane (2 mL), treated with methanesulfonyl chloride (40 μL) and stirred for 12 hours at room temperature. The mixture is partitioned between ethylacetate and water. The organic phase is washed with brine, dried (MgSO4) and concentrated to give the title compound, which is used directly in the next step. LC (method 5): tR=1.19 min; Mass spectrum (ESI+): m/z=794 [M+H]+.

Provenance & Evidence