MLN4924 hydrochloride → Pevonedistat

Participants

Reaction Steps

8 volumes of H2O were added to amorphous ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate hydrochloride (100 mg), which was matured using 4 hour heat/cool cycles (RT to 40° C.) for 3 days with shaking. The resulting solid was filtered under vacuum without further drying. XRPD data for Form 2 is shown in FIG. 4 and Table 2; DSC and TGA data for Form 2 are both shown in FIG. 5.

Provenance & Evidence