HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715688Generated: October 31, 2026
Tetrahydrofuran → HCID 58072081, compound
https://huagongshe.com/reaction/715688
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Trimethylboroxine | HCID 574072 | — |
| Reactant | 3-bromo-4,5-dimethoxybenzonitrile | HCID 735526 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 58072081 | HCID 58072081 | — |
Reaction Steps
50 mg [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium (II) and 5 mL tetrahydrofuran was stirred for 10 min at ambient temperature before 500 mg 3-bromo-4,5 dimethoxybenzonitrile, 0.1 mL trimethylboroxine and 0.85 g cesium carbonate as a solution in 1 mL water were added. The suspension was stirred at 100° C. for 4 h and then diluted with water and ethyl acetate. The phases were separated and the water phase was extracted with additional ethyl acetate (×2). The organic phases were combined, dried over magnesium sulfate and concentrated. The residue was purified with silica gel chromatography (SiO2: cyclohexane/ethyl acetate 9:1 to 7:3) to provide 4.17.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09187478B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-c6b948298d8b44798073e53c993e1417 |
|---|
| Source note | uspto-grants-2015_11 |
|---|
