Phosphorus oxychloride → 5-Chloro-7-(4-(trifluoromethoxy)phenyl)-1,6-naphthyridine

Participants

Reaction Steps

200 mg 7-(3-fluoro-4-trifluormethoxy-phenyl)[1,6]-naphthyridine-5-ol (5.1) and 10 μL N,N-diethylaniline were stirred into 4 mL phosphorus oxychloride overnight at 120° C. The reaction mixture was evaporated down, followed by co-evaporation with toluene (×3) and the residue purified via silica gel chromatography (ethyl acetate dichloromethane/methanol 4:1).

Provenance & Evidence