反应详情

温度

25 °C

103 g of a mixture of diastereoisomers (R/S)-4-acetyl-1-[(S)-1-(4-methoxyphenyl)-ethyl]-pyrrolidine-2-one is dissolved in 155 mL 1-butanol at 25° C. 18 mL benzyltrimethylammonium hydroxide (40% solution in methanol) is added. The solution is stirred for 30 minutes at 25° C. The solution is cooled to 0° C. Precipitation starts. The suspension is stirred for 15 minutes at 0° C. 100 mL n-heptane is added slowly and the suspension is stirred for 30 minutes at 0° C. The addition of 100 mL portions of n-heptane is repeated 4 times with subsequent stirring of the suspension at 0° C. for 30 minutes. The precipitate is isolated, washed with n-heptane and dried at 50° C.

1. temperatureThe solution is cooled to 0° C
2. customPrecipitation
3. stirringThe suspension is stirred for 15 minutes at 0° C
4. addition100 mL n-heptane is added slowly
5. stirringthe suspension is stirred for 30 minutes at 0° C
6. additionThe addition of 100 mL portions of n-heptane
7. stirringwith subsequent stirring of the suspension at 0° C. for 30 minutes
8. customThe precipitate is isolated
9. washwashed with n-heptane
10. customdried at 50° C.