Sodium Hydroxide → HCID 86701047, compound

HRID 715735Notes

Reaction equation

HRID 715735 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]2[N:13]=[C:14]([S:17][CH:18]([CH2:24][CH3:25])[C:19]([O:21]CC)=[O:20])[CH:15]=[CH:16][C:11]2=[N:10][N:9]=1.[OH-].[Na+]>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]2[N:13]=[C:14]([S:17][CH:18]([CH2:24][CH3:25])[C:19]([OH:21])=[O:20])[CH:15]=[CH:16][C:11]2=[N:10][N:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86701046HCID 86701046, compound

Product 1

HCID 86701047HCID 86701047, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of ethyl 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoate (1 mmol) in dioxane (3 mL) was added 0.5 ml of sodium hydroxide (2N), and the reaction mixture was stirred at room temperature. After 2 hours, the mixture was evaporated to dryness, and the obtained residue dissolved in water (2 mL) and then acidified with an hydrochloric acid solution. The resulting precipitate was filtered, washed with water, and dried to give 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoic acid.

Workup

  1. customthe mixture was evaporated to dryness
  2. dissolutionthe obtained residue dissolved in water (2 mL)
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-212673257a9e483fbcda49c7e081696e
Source dataset
uspto-grants-2015_11
Patent number
US09187484B2

Reaction notes

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