Sodium hydride → HCID 86701050, compound

Participants

Reaction Steps

Sodium hydride (1.5 equiv., 60% in mineral oil) was added at 0° C. to a solution of ethyl 2-hydroxybutyrate (1.5 equiv.) in dry DMF (7 mL) under argon atmosphere and the mixture was stirred for 10 min. To this mixture was added 6-chloro-3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazine (1 mmol) dissolved in DMF (3 mL). After 30 min, TLC showed that all the staring material was consumed. The solution was extracted with ethyl acetate, washed with water twice and concentrated. The crude syrup thus obtained was purified by flash column chromatography to give ethyl 2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)butanoate.

Provenance & Evidence