HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715805Generated: October 27, 2026
Lithium Hydroxide → Lithium 2-(1-phenylpiperidin-4-yl)thiazole-5-carboxylate
https://huagongshe.com/reaction/715805
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 2-(1-phenylpiperidin-4-yl)thiazole-5-carboxylate | HCID 86701984 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | Lithium 2-(1-phenylpiperidin-4-yl)thiazole-5-carboxylate | HCID 86701985 | — |
Reaction Steps
A solution of ethyl 2-(1-phenylpiperidin-4-yl)thiazole-5-carboxylate (31 mg, 0.098 mmol) in 1 ml of 1:1 tetrahydrofuran/methanol was treated with 1M aqueous LiOH (0.11 ml, 0.11 mol) and stirred at 65° C. for 3 hours. The mixture was taken to dryness and used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187472B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-4db2e0fb77b243f8b93a5b03fdbf089e |
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| Source note | uspto-grants-2015_11 |
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