HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate → HCID 68264555, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate | HCID 735736 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2774010 | — |
| Reactant | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68264555 | HCID 68264555 | — |
Reaction Steps
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.500 g, 2.58 mmol), tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (0.593 g, 2.58 mmol) and 2-(tributylphosphoranylidene)acetonitrile (0.746 g, 3.09 mmol) were stirred together in toluene (10 ml) at 85° C. overnight. The reaction was concentrated and purified by normal phase chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187472B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-ac557348b7db4883ad2a122514d6e793 |
| Source note | uspto-grants-2015_11 |