2-Chloro-5-isopropylpyrimidine → 4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-2-{1-[5-(propan-2-yl)pyrimidin-2-yl]piperidin-4-yl}-5,6,7,8-tetrahydroquinolin-5-ol

Participants

Reaction Steps

Reactions similar to those of the first step of Example 2 and Example 38 were performed except for using 2-chloro-5-(propan-2-yl) pyrimidine instead of 5-bromo-2-chloropyrimidine, and from 96 mg (0.14 mmol) of (−)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-2-(piperidin-4-yl)-5,6,7,8-tetrahydroquinoline, which was prepared by a method similar to that of Reference Example 10, 47 mg of the title compound was obtained as a white solid (yield: 50%).

Provenance & Evidence