Isopropyl iodide → (-)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-2-{1-[5-(propan-2-yloxy)pyrimidin-2-yl]piperidin-4-yl}-5,6,7,8-tetrahydroquinolin-5-ol

Participants

Reaction Steps

Reactions similar to those of Example 13 were performed except for using isopropyl iodide instead of ethyl iodide and setting the reaction temperature to 50° C., and from 60 mg (90 μmol) of (−)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-hydroxypyrimidin-2-yl)piperidin-4-yl]-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Example 4, 54 mg of the title compound was obtained as a white solid (yield: 90%).

Provenance & Evidence