2-Chloro-5-pentylpyrimidine → (-)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-2-[1-(5-pentylpyrimidin-2-yl)piperidin-4-yl]-5,6,7,8-tetrahydroquinolin-5-ol

Participants

Reaction Steps

Reactions similar to those of the first step of Example 2 and Example 38 were performed except for using 2-chloro-5-pentyl pyrimidine instead of 5-bromo-2-chloropyrimidine, and from 100 mg (0.148 mmol) of (−)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-2-(piperidin-4-yl)-5,6,7,8-tetrahydroquinoline, which was prepared by a method similar to that of Reference Example 10, 95 mg of the title compound was obtained as a white solid (yield: 91%).

Provenance & Evidence