1-Iodo-3-methylbutane → (-)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-2-{1-[5-(3-methylbutoxy)pyrimidine-2-yl]piperidin-4-yl}-5,6,7,8-tetrahydroquinoline-5-ol

Participants

Reaction Steps

Reactions similar to those of Example 21 were performed except for using 62 (0.47 mmol) of 1-iodo-3-methylbutane instead of 1-iodo-2-methylpropane, and from 55 mg (0.085 mmol) of (−)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-hydroxypyrimidin-2-yl)piperidin-4-yl]-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Example 4, 40 mg of the title compound was obtained as a white solid (yield: 65%).

Provenance & Evidence