Ethyl 5-bromovalerate → 2-{1-[5-(4-Ethoxycarbonylbutoxy)pyrimidin-2-yl]piperidin-4-yl}-4-(4,4-difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Participants

Reaction Steps

Reactions similar to those of Example 13 were performed except for using ethyl 5-bromovalerate instead of ethyl iodide, and from 85 mg (0.13 mmol) of (−)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-hydroxypyrimidin-2-yl)piperidin-4-yl]-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Example 10, the crude title compound was obtained. The total amount of the obtained compound was used in Example (23-2).

Provenance & Evidence