Dimethylamine → HCID 86682442, compound

HRID 715870Notes

Reaction equation

HRID 715870 reaction equation
[CH3:1][NH:2][CH3:3].[C:4]([C:7]1[CH:8]=[N:9][C:10]([N:13]2[CH2:18][CH2:17][CH:16]([C:19]3[C:28]([CH:29]([F:40])[C:30]4[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=4)=[C:27]([CH:41]4[CH2:46][CH2:45][C:44]([F:48])([F:47])[CH2:43][CH2:42]4)[C:26]4[CH:25]([O:49]CC5C=CC(OC)=CC=5)[CH2:24][C:23]([CH3:60])([CH3:59])[CH2:22][C:21]=4[N:20]=3)[CH2:15][CH2:14]2)=[N:11][CH:12]=1)([OH:6])=O>>[F:47][C:44]1([F:48])[CH2:43][CH2:42][CH:41]([C:27]2[C:26]3[CH:25]([OH:49])[CH2:24][C:23]([CH3:60])([CH3:59])[CH2:22][C:21]=3[N:20]=[C:19]([CH:16]3[CH2:17][CH2:18][N:13]([C:10]4[N:9]=[CH:8][C:7]([C:4](=[O:6])[N:2]([CH3:3])[CH3:1])=[CH:12][N:11]=4)[CH2:14][CH2:15]3)[C:28]=2[CH:29]([F:40])[C:30]2[CH:31]=[CH:32][C:33]([C:36]([F:38])([F:39])[F:37])=[CH:34][CH:35]=2)[CH2:46][CH2:45]1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 86682443HCID 86682443, compound

Product 1

HCID 86682442HCID 86682442, compound

Procedure

Reactions similar to those of the second step of Reference Example 25 and Example 38 were performed except for using dimethylamine aqueous solution instead of methylamine aqueous solution, and from 70 mg of the crude product of 2-[1-(5-Carboxypyrimidin-2-yl)piperidin-4-yl]-4-(4,4-difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-5,6,7,8-tetrahydroquinoline, which was prepared in the first step of Reference Example 25, 30 mg of the title compound was obtained as a white solid (yield: 56%).

Sources & evidence

ORD record
ord-5d2f0ccb10254f949c51b1f0918bc372
Source dataset
uspto-grants-2015_11
Patent number
US09187450B2

Reaction notes

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