Morpholine → HCID 86682444, compound

Participants

Reaction Steps

Reactions similar to those of the second step of Reference Example 25 and Example 38 were performed except for using morpholine instead of methylamine aqueous solution, and from 70 mg of the crude product of 2-[1-(5-Carboxypyrimidin-2-yl)piperidin-4-yl]-4-(4,4-difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-5,6,7,8-tetrahydroquinoline, which was prepared in the first step of Reference Example 25, 27 mg of the title compound was obtained as a white solid (yield: 49%).

Provenance & Evidence