Trifluoroacetic acid → HCID 86682452, compound

Participants

Reaction Steps

To a solution of 86 mg (99 μmol) of 4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-2-(1-{5-[(1-methylpiperidin-4-yl)oxy]pyrimidin-2-yl}piperidin-4-yl)-5,6,7,8-tetrahydroquinoline, which was prepared by a method similar to that of Reference Example 29, in 1.0 ml of dichloromethane, 0.2 ml of anisole and 0.2 ml of trifluoroacetic acid were added, and the reaction solution was stirred at room temperature for 12 hours. After completion of the reaction, the solvent in the reaction solution and trifluoroacetic acid were distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography [dichloromethane/methanol/28% ammonia water=100/0/0-90/9.5/0.5 (V/V/V)] and thin layer chromatography [dichloromethane/methanol/28% ammonia water=90/9.5/0.5 (V/V/V)] to provide 12 mg of the title compound as a white solid (yield: 17%).

Provenance & Evidence