(3-Bromopropoxy)(tert-butyl)dimethylsilane → HCID 86682462, compound

Participants

Reaction Steps

Reactions similar to those of Example 13 were performed except for using (3-bromopropoxy) (tert-butyl)dimethylsilane instead of ethyl iodide, and from 61 mg (94 μmol) of (−)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-hydroxypyrimidin-2-yl)piperidin-4-yl]-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Example 4, 71 mg (87 μmol) of 2-{1-[5-(3-{[tert-Butyl(dimethyl)silyl]oxy}propoxy)pyrimidin-2-yl]piperidin-4-yl}-4-(4,4-difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol was obtained.

Provenance & Evidence