反应详情

Reactions similar to those of Example 39 were performed except for using (2,2-dimethyl-1,3-dioxan-5-yl)methyl p-toluenesulfonate, which was synthesized with the method described in J. Dubois et al., Tetrahedron, 1991, Vol. 47, pp. 1001-1012, instead of (S)-(+)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate, and from 4.04 g (6.23 mmol) of (−)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-hydroxypyrimidin-2-yl)piperidin-4-yl]-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Example 4, 2.73 g of the title compound was obtained as a white solid (yield: 59%).

1. customwas synthesized with the method