2-Propanesulfonyl chloride → HCID 76372212, compound

HRID 715886Notes

Reaction equation

HRID 715886 reaction equation
[CH:1]([S:4](Cl)(=[O:6])=[O:5])([CH3:3])[CH3:2].[F:8][C:9]1([F:55])[CH2:14][CH2:13][CH:12]([C:15]2[C:24]3[CH:23]([OH:25])[CH2:22][C:21]([CH3:27])([CH3:26])[CH2:20][C:19]=3[N:18]=[C:17]([CH:28]3[CH2:33][CH2:32][N:31]([C:34]4[N:39]=[CH:38][C:37]([CH2:40][NH:41][CH3:42])=[CH:36][N:35]=4)[CH2:30][CH2:29]3)[C:16]=2[CH:43]([F:54])[C:44]2[CH:49]=[CH:48][C:47]([C:50]([F:53])([F:52])[F:51])=[CH:46][CH:45]=2)[CH2:11][CH2:10]1>>[F:55][C:9]1([F:8])[CH2:10][CH2:11][CH:12]([C:15]2[C:24]3[CH:23]([OH:25])[CH2:22][C:21]([CH3:27])([CH3:26])[CH2:20][C:19]=3[N:18]=[C:17]([CH:28]3[CH2:29][CH2:30][N:31]([C:34]4[N:39]=[CH:38][C:37]([CH2:40][N:41]([CH3:42])[S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])=[CH:36][N:35]=4)[CH2:32][CH2:33]3)[C:16]=2[CH:43]([F:54])[C:44]2[CH:45]=[CH:46][C:47]([C:50]([F:51])([F:53])[F:52])=[CH:48][CH:49]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 86682466HCID 86682466, compound

Product 1

HCID 76372212HCID 76372212, compound

Procedure

Reactions similar to those of Example 51 were performed except for using isopropylsulfonyl chloride instead of methanesulfonyl chloride, and from 64 mg (94 μmol) of 4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-2-(1-{5-[(methylamino)methyl]pyrimidin-2-yl}piperidin-4-yl)-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Example 58, 14 mg of the title compound was obtained as a white solid (yield: 19%).

Sources & evidence

ORD record
ord-c20145d192c14ac191dd76b5e77ca093
Source dataset
uspto-grants-2015_11
Patent number
US09187450B2

Reaction notes

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