反应详情

Reactions similar to those of the first step of Example 2 and Example 38 were performed except for using 2-chloro-5-(methylsulfonyl)pyrimidine, which was prepared by a method similar to that of Reference Example 14, instead of 5-bromo-2-chloropyrimidine, and from 49 mg (72 μmol) of (−)-4-(4,4-Difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-2-(piperidin-4-yl)-5,6,7,8-tetrahydroquinoline, which was prepared by a method similar to that of Reference Example 10, 45 mg of the title compound was obtained as a white solid (yield: 88%).

1. customwas prepared by a method similar to that of Reference Example 14