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HRID71590

反应详情

EQUATION

反应方程式

HRID 71590 的结构方程式

REACTANTS

反应物

2
结构：Nc1cccc(-c2cnco2)c1
HCID2739289

3-(1,3-oxazol-5-yl)aniline

C9H8N2O

结构：Oc1cccc(Nc2nc(Cl)ncc2F)c1
HCID22060451

未命名化合物

PRODUCTS

生成物

1
结构：Oc1cccc(Nc2nc(Nc3cccc(-c4cnco4)c3)ncc2F)c1
HCID22060603

未命名化合物

PROCEDURE

实验过程

In like manner to the preparation of N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidineamine, the reaction of 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine with 3-(1,3-oxazol-5-yl)aniline gave 5-fluoro-N4-(3-hydroxyphenyl)-N2-(3-(1,3-oxazol-5-yl)phenyl]-2,4-pyrimidinediamine. LCMS: purity: 76%; MS (m/e): 364 (MH+).

WORKUP

后处理

  1. customIn like manner to the preparation of N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidineamine