HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3,3-Trifluoro-1-propanol → 2-Chloro-5-(3,3,3-trifluoropropoxy)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3,3-Trifluoro-1-propanol | HCID 137512 | — |
| Reactant | 2-Chloro-5-pyrimidinol | HCID 14595700 | — |
| Product | 2-Chloro-5-(3,3,3-trifluoropropoxy)pyrimidine | HCID 86682464 | 92% |
Reaction Steps
Reactions similar to those of Reference Example 28 were performed except for using 3,3,3-trifluoro-1-propanol instead of 1-methyl-4-piperidinol, and from 100 mg (0.693 mmol) of 2-chloro-5-hydroxypyrimidine, 144 mg of the title compound as a colorless oil (yield: 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187450B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-5bff100e3a8d4df7803e07f432ef442d |
| Source note | uspto-grants-2015_11 |