Cesium carbonate → HCID 117874690, compound

Participants

Reaction Steps

Tert-butanol (17.4 ml), water (17.4 ml), and a 1 M aqueous copper(II) sulfate solution (4.64 ml) were added to sodium chlorodifluoroacetate (3.54 g), but-3-yn-2-ol (2.00 ml), sodium azide (1.66 g), cesium carbonate (11.3 g), and copper (1.18 g), and the mixture was reacted for 30 minutes using a microwave reaction apparatus (300 W, 125° C.). The reaction solution was diluted with ethyl acetate. While being washed, the dilution was filtered to remove the aqueous layer. The organic layer was dried over anhydrous sodium sulfate and then filtered. The solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-hexane-methyl acetate) to obtain the title compound (196 mg).

Provenance & Evidence