HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715921Generated: October 28, 2026
Itaconic acid → 1-(4-bromophenyl)-5-oxopyrrolidine-3-carboxylic acid
https://huagongshe.com/reaction/715921
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Itaconic acid | HCID 811 | — |
| Reactant | 4-Bromoaniline | HCID 7807 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 1-(4-bromophenyl)-5-oxopyrrolidine-3-carboxylic acid | HCID 2912208 | 95.1% |
Reaction Steps
A mixture of 4-bromoaniline (8.6 g) and itaconic acid (6.5 g) was stirred at 130° C. for 50 minutes. After cooling, a n-hexane-ethyl acetate mixed solution was added to the resulting solid. The compound was collected by filtration to obtain the title compound (13.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187489B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-ccaf1d096ab048188b6f2084bb2a7bb1 |
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| Source note | uspto-grants-2015_11 |
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