Sodium hydride → HCID 117874477, compound

Participants

Reaction Steps

To a solution of 3-fluorobenzyl alcohol (0.59 g) in N,N-dimethylformamide (20 ml), sodium hydride (55% oil, 0.26 g) was added under ice cooling, and the mixture was stirred at the same temperature as above for 10 minutes. 3-Bromo-6-chloroimidazo[1,2-b]pyridazine (1 g) was added to the reaction solution, and the mixture was stirred at the same temperature as above for 1 hour. A saturated aqueous solution of ammonium chloride was added to the reaction solution, followed by extraction with ethyl acetate. The extract was washed with water and saturated saline in this order and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The obtained residue was washed with n-hexane to obtain the title compound (1.2 g).

Provenance & Evidence