Maleic Acid → HCID 72695816, compound

Participants

Reaction Conditions

Reaction Steps

To N-[(1R)-1-(3-fluorophenyl)ethyl]-3-[4-[[(2S)-pyrrolidin-2-yl]methoxy]phenyl]imidazo[1,2-b]pyridazin-6-amine (105 mg) obtained in Example 24, water (1.8 ml) and a 1 mol/l aqueous maleic acid solution (242 μl) were added at room temperature. Then, the mixture was stirred at 40° C. for 20 hours and further stirred at room temperature for 0.5 hours. Then, the deposited solid was collected by filtration to obtain the title compound (112 mg).

Provenance & Evidence