2-Bromo-4-fluorobenzene-1-sulfonyl chloride → Methyl (S)-7-(2-bromo-4-fluorobenzenesulfonylamino]-2,3,3a,4-tetrahydro-1 H-benzo[b]pyrrolo[1,2-d][1,4]oxazine-6-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-4-fluorobenzene-1-sulfonyl chloride	HCID 2778216	—
Reactant	methyl (R)-7-(2-bromo-4-fluorobenzenesulfonylamino]-2,3,3a,4-tetrahydro-1H-benzo[b]pyrrolo[1,2-d][1,4]oxazine-6-carboxylate	HCID 71003749	—
Reactant	Methyl (S)-7-amino-2,3,3a,4-tetrahydro-1H-benzo[b]pyrrolo[1,2-d][1,4]oxazine-6-carboxylate	HCID 86712112	—
Product	Methyl (S)-7-(2-bromo-4-fluorobenzenesulfonylamino]-2,3,3a,4-tetrahydro-1 H-benzo[b]pyrrolo[1,2-d][1,4]oxazine-6-carboxylate	HCID 71003669	—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 2, starting from methyl (S)-7-amino-2,3,3a,4-tetrahydro-1H-benzo[b]pyrrolo[1,2-d][1,4]oxazine-6-carboxylate (Intermediate 13), and 2-bromo-4-fluorobenzenesulfonyl chloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09187494B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-9642fa5b2edf4f74bd04092d26708886
Source note	uspto-grants-2015_11