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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715951Generated: October 30, 2026

tert-butyl (S)-2-[6-bromo-3-bis-(tert-butoxycarbonyl)amino-2-methoxycarbonylphenoxy-methyl]pyrrolidine-1-carboxylate → methyl 6-amino-3-bromo-2-((S)-1-pyrrolidin-2-ylmethoxy)benzoate

https://huagongshe.com/reaction/715951

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl (S)-2-[6-bromo-3-bis-(tert-butoxycarbonyl)amino-2-methoxycarbonylphenoxy-methyl]pyrrolidine-1-carboxylateHCID 71003911—
Reactantmethyl 6-amino-3-bromo-2-((R)-1-pyrrolidin-2-ylmethoxy)benzoateHCID 86712110—
Productmethyl 6-amino-3-bromo-2-((S)-1-pyrrolidin-2-ylmethoxy)benzoateHCID 86712113—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 7, starting from tert-butyl (S)-2-[6-bromo-3-bis-(tert-butoxycarbonyl)amino-2-methoxycarbonylphenoxy-methyl]pyrrolidine-1-carboxylate (Intermediate 15).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187494B2
Source datasetuspto-grants-2015_11
ORD IDord-e0566cd25e634a36a423540913b8fbd7
Source noteuspto-grants-2015_11