HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl 7-(2-bromo-4-fluorobenzenesulfonylamino]-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-8-carboxylate → methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-8-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl 7-(2-bromo-4-fluorobenzenesulfonylamino]-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-8-carboxylate | HCID 70984706 | — |
| Reactant | N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)amine | HCID 86684726 | — |
| Reactant | methyl (R)-7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzene-sulfonylamino]-2,3,3a,4-tetrahydro-1H-benzo[b]pyrrolo[1,2-d][1,4]oxazine-6-carboxylate | HCID 86712100 | — |
| Product | methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-8-carboxylate | HCID 86712102 | — |
Reaction Steps
Prepared by proceeding in a similar manner to Intermediate 1, starting from methyl 7-(2-bromo-4-fluorobenzenesulfonylamino]-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-8-carboxylate (Intermediate 28) and N,N-diethyl-N—((Z)-1-tributyl-stannanylprop-1-en-3-yl)-amine (Intermediate 3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187494B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-18e14da7432f445fbc74693bee7d4dd1 |
| Source note | uspto-grants-2015_11 |