HCID 71003668, compound → HCID 86712119, compound

Participants

Reaction Steps

A solution of tert-butyl (R)-6-benzyloxycarbonylamino-1,2,2a,3-tetrahydro-4-oxa-8b-aza-cyclobuta[a]naphthalene-5-carboxylate (Intermediate 45, 0.138 g) in ethanol (20 mL) was treated with 10% palladium on carbon (0.05 g) and the resultant mixture was stirred under an atmosphere of hydrogen for 30 minutes. The mixture was filtered and the filtrate was concentrated in vacuo to give tert-butyl (R)-6-amino-1,2,2a,3-tetrahydro-4-oxa-8b-azacyclobuta[a]naphthalene-5-carboxylate (0.092 g) as a pale yellow solid.

Provenance & Evidence