HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 716008Generated: October 25, 2026
Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → (E)-methyl 4-(2-nitrophenyl)but-2-enoate
https://huagongshe.com/reaction/716008
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester | HCID 17453 | — |
| Reactant | 2-Nitrobenzeneacetaldehyde | HCID 10844764 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-methyl 4-(2-nitrophenyl)but-2-enoate | HCID 15264372 | — |
| Product | (E)-Methyl 4-(2-nitrophenyl)but-3-enoate | HCID 20269937 | — |
Reaction Steps
A mixture of 2-(2-nitrophenyl)acetaldehyde (760 mg, 4.6 mmol) and methoxylcarbonylmethylenetriphenylphosphorane (1.5 g, 4.6 mmol) in toluene (10 mL) was heated at 110° C. for 3 hours. The crude material was purified by silica gel column chromatography eluting with hexanes and ethyl acetate (2:1) to afford the title compound along with (E)-methyl 4-(2-nitrophenyl)but-2-enoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187483B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-bde7d12ffb644ed1aa14dc738b1a44a5 |
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| Source note | uspto-grants-2015_11 |
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