Piperidine, acetate → 2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

Participants

Reaction Conditions

Reaction Steps

To a 35 ml reaction vial, 4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzaldehyde (0.200 g, 0.0004 mole) and 3-(4-methylpiperazin-3-oxopropanenitrile (0.211 g, 0.0013 mole) was taken in ethanol (10 ml). To this, piperidine acetate (3.3 M solution in water) (3 ml, 0.0099 mole) was added at RT and the reaction mixture was heated to 80° C. for 16 hr. After completion of the reaction, ethanol was evaporated under reduced pressure from the reaction mixture and then diluted with EtOAc (20 ml). The organic layer was washed with water, dried over Na2SO4 and evaporated to get product which was subjected for the column purification. The crude compound was purified using column purification using 60-120 mesh size neutral silica by eluting the compound with 2% MeOH in CH2Cl2 to yield 0.25 g of 2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile.

Provenance & Evidence