Trifluoroacetic acid → HCID 71014413, compound

Participants

Reaction Conditions

Reaction Steps

To a 20 ml vial, 3-[4-[[7-(2,2-dimethylpropanoyl)-5-(2-trimethylsilylethoxymethyl)-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-2-(piperidine-1-carbonyl)prop-2-enenitrile (0.04 ml, 0.04 mmol) was dissolved in DCM (3 ml) and the reaction mixture was cooled to 0° C. TFA (2 ml, 0.0238 mole) was added drop wise at 0° C. and there reaction mixture was stirred for 3 h at room temperature. The solvent was evaporated and the residue was neutralized by NaHCO3 to pH 7-8 and the aq. layer was extracted with EtOAc. The organic layer was evaporated and the residue was dissolved in methanol. HCl and water were added and the solution was stirred at RT overnight and then neutralized with NaHCO3 to pH7-8. The crude product which precipitated was filtrated, washed with water and dried. The crude product was dissolved in a mixture of EtOAC and CH2Cl2, loaded on TLC plate and flashed with EtOAc:hexane=85:15 to yield 0.014 g of 3-[4-[[7-(2,2-dimethylpropanoyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]amino]phenyl]-2-(piperidine-1-carbonyl)prop-2-enenitrile.

Provenance & Evidence