反应详情

To a 20 ml vial 2-[4-(2-cyano-3-morpholino-3-oxo-prop-1-enyl)anilino]-N-isopropyl-5-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-b]pyrazine-7-carboxamide (65 mg, 0.11 mmol was dissolved in DCM (3 ml) added TFA (3 ml, 0.11 mmol) was added. The reaction mixture was stirred overnight. HCl (1 ml, 0.11 mmol) and methanol (3 ml) were added and the reaction mixture was stirred at overnight and then neutralized to pH 6-7 with NaHCO3. The organics were extracted with EtOAc, washed with water, dried with Na2SO4, filtered and evaporated solvent to give 45 mg of 2-[4-(2-cyano-3-morpholino-3-oxo-prop-1-enyl)anilino]-N-isopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide as yellow solid.

1. additionwas added
2. stirringthe reaction mixture was stirred at overnight
3. extractionThe organics were extracted with EtOAc
4. washwashed with water
5. dry with materialdried with Na2SO4
6. filtrationfiltered
7. customevaporated solvent