Trifluoroacetic acid → HCID 77981870, compound

Participants

Reaction Steps

To a 25 ml one necked round bottom flask, 3-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)-2-(1H-1,2,4-triazol-1-yl)acrylonitrile (0.052 g, 0.95 mmole) was taken in CH2Cl2 (5 mL). TFA (1.5 mL) was added drop wise at 0° C. After completion of the addition, the reaction mass was warmed up to RT and stirred for 16 hrs at the same temperature. After completion of the reaction, CH2Cl2 was distilled out to get solid. The solid was taken in ethanol (10 mL) and sodium acetate trihydrate (0.130 g, 0.95 mmole) was added at RT. The reaction mixture was stirred for 20 hrs at RT. After completion of the reaction the ethanol was distilled out under vacuum. To the residue, water (20 mL) was added and stirred for 15 min, filtered and wash with water and n-pentane. The solid was dried under vacuum to yield 21 mg of 3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)-2-(1H-1,2,4-triazol-1-yl)acrylonitrile.

Provenance & Evidence