Water → HCID 86687812, compound

Participants

Reaction Conditions

Reaction Steps

KBr (0.6 g, 0.005 mol) and NaHCO3 (6.4 g, 0.076 mol) and 0.8 g (0.00566 mols) 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) were mixed together with water (60 ml), toluene (250 g) and 4-cyclopentyl-3-methylbutan-1-ol (70.2 g 0.45 mol, purity:98%) the reaction temperature maintain 0° C. with continuous stirring. NaOCl (12% w/w aqueous 426.8 g, 0.745 mol) was added to the reaction mass over 2 h. Stirring was continued for another 12 h. The aqueous phase was removed, organic phase was washed with a solution of NaHCO3 and then with water. The organic phase thus obtained was concentrated and crude product purified by fractional distillation to provide 4-cyclopentyl-3-methylbutanal (41.58 g, yield: 60%, GC purity: 97%)

Provenance & Evidence