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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 716507Generated: October 31, 2026

Proline benzyl ester hydrochloride → (S)-Benzyl 1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidine-2-carboxylate

https://huagongshe.com/reaction/716507

Reaction equation

Participants

RoleNameHCIDCharge
ReactantProline benzyl ester hydrochlorideHCID 2733413—
Reactant(2S)-2-((methoxycarbonyl)amino)-3-methylbutanoic acidHCID 10942966—
Reactant(S,R)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)-pyrrolidine-2-carboxylic acid benzyl esterHCID 15288611—
Product(S)-Benzyl 1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidine-2-carboxylateHCID 67240149—

Reaction Steps

Compound 2b was synthesized from compound 1 (2 mmol) and L-proline benzyl ester hydrochloride (2.2 mmol), following the procedure as described for compound 2a.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187496B2
Source datasetuspto-grants-2015_11
ORD IDord-24974ac291f2436db2f4c9a2f2498bfe
Source noteuspto-grants-2015_11