HuagongsheHuagongshe Chemistry Print Report · For research reference only
Proline benzyl ester hydrochloride → (S,S)-1-(2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Proline benzyl ester hydrochloride | HCID 2733413 | — |
| Reactant | (2S)-2-(((tert-butoxy)carbonyl)amino)-2-phenylacetic acid | HCID 11010409 | — |
| Reactant | (S,R)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)-pyrrolidine-2-carboxylic acid benzyl ester | HCID 15288611 | — |
| Product | (S,S)-1-(2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid benzyl ester | HCID 67239936 | — |
Reaction Steps
Compound 21 was synthesized from Boc-L-phenylglycine and L-proline benzyl ester hydrochloride, following the procedure as described for compound 2a, as a white crystallized solid. MS (ESI, EI+) m/z=439 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187496B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-197768ab70634cdfb5ca819a4d79a27f |
| Source note | uspto-grants-2015_11 |