Boc-gly-pro-OH → (S)-{2-[2-(2-bromo-imidazo[2,1-b]thiazol-6-ylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	Boc-gly-pro-OH	HCID 11673468	—
Reactant	2-Bromo-imidazo[2,1-b]thiazol-6-ylamine hydrochloride	HCID 67240528	—
Reactant	(S,S) {2-[2-(2-bromo-imidazo[2,1-b]thiazol-6-ylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl}-carbamic acid tert-butyl ester	HCID 67241361	—
Product	(S)-{2-[2-(2-bromo-imidazo[2,1-b]thiazol-6-ylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester	HCID 67239851	46%

Reaction Steps

Compound 28 was synthesized from compound 11 (0.471 mmol) and compound 27 (0.707 mmol), following the procedure as described for compound 23, as an off-white solid in 46% yield. MS (ESI, EI+) m/z=471.99-474.01 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09187496B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-e104f9fa4ba543088edecc87b795062b
Source note	uspto-grants-2015_11