HuagongsheHuagongshe Chemistry Print Report · For research reference only
Proline benzyl ester hydrochloride → 1-[(R)-methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Proline benzyl ester hydrochloride | HCID 2733413 | — |
| Reactant | (alphaR)-alpha-((Methoxycarbonyl)amino)benzeneacetic acid | HCID 10910775 | — |
| Reactant | (S,R)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)-pyrrolidine-2-carboxylic acid benzyl ester | HCID 15288611 | — |
| Product | 1-[(R)-methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester | HCID 54280770 | — |
Reaction Steps
Compound 32 was synthesized from compound 31 and L-proline benzyl ester hydrochloride, following the procedure as described for compound 2a, as a white crystallized solid. MS (ESI, EI+) m/z=397 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187496B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-bdbc014805974eecb0682ee5456b2aad |
| Source note | uspto-grants-2015_11 |